SG-APSIC1095: Acquisition rate of carbapenemase-producing organisms (CPOs) among hospital contacts of CPO patients: An interim subgroup analysis of a cohort study

Objectives: The increase in carbapenemase-producing organism (CPO) transmission among hospitalized patients is a growing concern. Studies investigating the of CPO to epidemiologically linked contacts are scarce. We conducted an interim subgroup analysis ongoing multicenter household Singapore (CaPES-C) study identify acquisition rate patients. Methods: This prospective cohort was between January and December 2021. recruited CPO-positive their contacts. Stool samples were collected from at baseline, day 3, 7, weeks 2, 4, 5, 6, 12, 24, 36, 48. Additionally, sample time discharge hospital. Xpert Carba-R test used detect genotypes stool samples. In this analysis, we calculated hospital positive using Stata version 15 software. Results: 22 (56.4%) index [ bla NDM, n = 7 (31.8%); IMP, 3 (13.6%); OXA-48, 10 (45.5%), others, 2 (9.1%)] 14 (35.9%) median age 72.5 years (IQR, 62–82) (68.2%) female. for 82.5 70–85) 4 (28.6%) After 1,082 patient days, (14.3%) tested giving 1.85 per 1,000 days (95% CI, 0.46 – 7.39). One these participants acquired concordant genotype ( OXA-48) other discordant (CPO index, IMP; contact, NDM) week 12 follow-up. Conclusions: small revealed high conversion A larger needed understand influence genotypes, environment, human behavior on hospitals.